{"id":2016,"date":"2018-11-28T14:52:20","date_gmt":"2018-11-28T13:52:20","guid":{"rendered":"http:\/\/www.mc-praha.cz\/mcp\/?p=2016"},"modified":"2024-02-05T10:14:08","modified_gmt":"2024-02-05T09:14:08","slug":"trombofilie","status":"publish","type":"post","link":"https:\/\/www.mc-praha.cz\/mcp\/trombofilie\/","title":{"rendered":"Trombofilie"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p style=\"background: white; vertical-align: baseline; margin: 0cm 0cm 7.5pt 0cm;\"><strong>Sr\u00e1\u017een\u00ed krve je fyziologick\u00e1 obrana t\u011bla p\u0159i \u00faniku krve v m\u00edst\u011b poran\u011bn\u00ed, \u010d\u00edm\u017e se zabezpe\u010duje zamezen\u00ed krv\u00e1cen\u00ed a n\u00e1sledn\u00e9 zacelen\u00ed r\u00e1ny. Tromboembolick\u00e1 nemoc (TEN) je onemocn\u011bn\u00ed charakterizovan\u00e9 vznikem krevn\u00edch sra\u017eenin a jejich vmeten\u00edm do c\u00e9v na jin\u00e9m m\u00edst\u011b t\u011bla. Typick\u00fdm p\u0159\u00edkladem je plicn\u00ed embolie. <\/strong><\/p>\n<p style=\"background: white; vertical-align: baseline; margin: 0cm 0cm 7.5pt 0cm;\">Sr\u00e1\u017elivost krve je \u0159\u00edzena n\u011bkolika faktory a enzymy, kter\u00e9 se pod\u00edlej\u00ed na vzniku a rozpu\u0161t\u011bn\u00ed sra\u017eenin (tromb\u016f).<\/p>\n<p style=\"background: white; vertical-align: baseline; margin: 0cm 0cm 7.5pt 0cm;\">Trombofiln\u00ed stavy jsou obvykle spojeny s p\u0159\u00edtomnost\u00ed mutac\u00ed v genech pro sr\u00e1\u017eec\u00ed faktory:<br \/>\n\u2013 dv\u011b bodov\u00e9 mutace v genu MTHFR (C677T; A1298C) (v\u00fdskyt obou t\u011bchto polymorfism\u016f v evropsk\u00e9 populaci 31\u201339 %)<br \/>\n\u2013 tzv. Leidensk\u00e1 mutace \u2013 v genu pro koagula\u010dn\u00ed blok\u00e1tor faktor V (v\u00fdskyt v evropsk\u00e9 populaci kolem 5 %)<br \/>\n\u2013 mutace v genu k\u00f3duj\u00edc\u00edm prothrombin neboli faktor II (v\u00fdskyt pouze kolem 1\u20132 %)<br \/>\n\u2013 mutace v inhibitoru aktiv\u00e1toru plasminogenu PAI-1 (v\u00fdskyt homozygot\u016f v \u010desk\u00e9 populaci je kolem 30 %).<\/p>\n<p style=\"background: white; vertical-align: baseline; margin: 0cm 0cm 7.5pt 0cm;\">Pokud je v genomu p\u0159\u00edtomno v\u00edce t\u011bchto mutac\u00ed najednou, jejich efekt je kumulativn\u00ed a riziko rozvoje trombofilie se tak v\u00fdrazn\u011b zvy\u0161uje.<\/p>\n<p style=\"background: white; vertical-align: baseline; margin: 0cm 0cm 7.5pt 0cm;\">\u017deny s genetickou predispozic\u00ed pro trombofilii, kter\u00e9 u\u017e\u00edvaj\u00ed hormon\u00e1ln\u00ed antikoncepci \u010di hormon\u00e1ln\u00ed terapii obsahuj\u00edc\u00ed estrogen, maj\u00ed extr\u00e9mn\u011b zv\u00fd\u0161en\u00e9 riziko vzniku ne\u017e\u00e1douc\u00edch sra\u017eenin (a\u017e 35x), nebo\u0165 l\u00e1tky estrogenn\u00edho typu v\u00fdznamn\u011b zvy\u0161uj\u00ed hladiny n\u011bkter\u00fdch sr\u00e1\u017eec\u00edch faktor\u016f (konkr\u00e9tn\u011b faktoru VII, X, XII a XIII). T\u011bhotenstv\u00ed u t\u011bchto \u017een se st\u00e1v\u00e1 rizikov\u00fdm a vy\u017eaduje zv\u00fd\u0161en\u00fd l\u00e9ka\u0159sk\u00fd dohled, pop\u0159. preventivn\u00ed terapii.<\/p>\n<p>&nbsp;<\/p>\n<p>Dal\u0161\u00ed podrobnosti naleznete na webov\u00fdch str\u00e1nk\u00e1ch <a href=\"http:\/\/www.qgen.cz\">www.qgen.cz<\/a><\/p>\n<p>Term\u00edn l\u00e9ka\u0159sk\u00e9ho vy\u0161et\u0159en\u00ed si m\u016f\u017eete rezervovat <a href=\"http:\/\/extranet.mc-praha.cz\/\">zde.<\/a><\/p>\n<p>Laboratorn\u00ed vy\u0161et\u0159en\u00ed si m\u016f\u017eete objednat<a href=\"https:\/\/extranet.mc-praha.cz\/#\/laboratory\"> zde<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; Sr\u00e1\u017een\u00ed krve je fyziologick\u00e1 obrana t\u011bla p\u0159i \u00faniku krve v m\u00edst\u011b poran\u011bn\u00ed, \u010d\u00edm\u017e se [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"link","meta":{"_uag_custom_page_level_css":""},"categories":[9],"tags":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"boldthemes_grid":false,"boldthemes_grid_11":false,"boldthemes_grid_22":false,"boldthemes_grid_21":false,"boldthemes_grid_12":false,"boldthemes_latest_posts":false,"boldthemes_grid_gallery":false},"uagb_author_info":{"display_name":"Jbednar","author_link":"https:\/\/www.mc-praha.cz\/mcp\/author\/jbednar\/"},"uagb_comment_info":0,"uagb_excerpt":"&nbsp; Sr\u00e1\u017een\u00ed krve je fyziologick\u00e1 obrana t\u011bla p\u0159i \u00faniku krve v m\u00edst\u011b poran\u011bn\u00ed, \u010d\u00edm\u017e se [&hellip;]","post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/2016"}],"collection":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/comments?post=2016"}],"version-history":[{"count":6,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/2016\/revisions"}],"predecessor-version":[{"id":4543,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/2016\/revisions\/4543"}],"wp:attachment":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/media?parent=2016"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/categories?post=2016"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/tags?post=2016"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}