{"id":2026,"date":"2018-11-28T14:55:45","date_gmt":"2018-11-28T13:55:45","guid":{"rendered":"http:\/\/www.mc-praha.cz\/mcp\/?p=2026"},"modified":"2024-02-05T10:18:12","modified_gmt":"2024-02-05T09:18:12","slug":"ccr5","status":"publish","type":"post","link":"https:\/\/www.mc-praha.cz\/mcp\/ccr5\/","title":{"rendered":"CCR5 &#8211; rezistence v\u016f\u010di viru HIV"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p style=\"background: white; vertical-align: baseline; margin: 0cm 0cm 7.5pt 0cm;\"><strong>CCR5 je bun\u011b\u010dn\u00fd chemokinov\u00fd receptor a je podobn\u011b jako jin\u00e9 receptory vstupn\u00ed branou pro infekce do bu\u0148ky, v tomto p\u0159\u00edpad\u011b pro virus lidsk\u00e9 imunodeficience (HIV). <\/strong><\/p>\n<p style=\"background: white; vertical-align: baseline; margin: 0cm 0cm 7.5pt 0cm;\">Mutace v genu pro CCR5 (tzv. CCR5 \u039432) vede k poru\u0161e exprese CCR5 na bun\u011b\u010dn\u00e9m povrchu a nedoch\u00e1z\u00ed tak k n\u00e1kaze bun\u011bk infekc\u00ed HIV.<\/p>\n<p style=\"background: white; vertical-align: baseline; margin: 0cm 0cm 7.5pt 0cm;\">Je zaj\u00edmav\u00e9, \u017ee se tato mutace b\u011b\u017en\u011b vyskytuje v populaci zejm\u00e9na v severn\u00ed Evrop\u011b, frekvence v\u00fdskytu sm\u011brem na jih kles\u00e1. V Africe a v\u00fdchodn\u00ed Asii se tak\u0159ka nevyskytuje (viz obr\u00e1zek).<\/p>\n<p style=\"background: white; vertical-align: baseline; margin: 0cm 0cm 7.5pt 0cm;\">V\u00fdskyt heterozygot\u016f neboli jedinc\u016f s jednou CCR5 \u039432 alelou je v \u010desk\u00e9 populaci p\u0159ibli\u017en\u011b 10 %. V\u00fdskyt homozygot\u016f, kte\u0159\u00ed maj\u00ed 2 alely, je p\u0159ibli\u017en\u011b 1 %.<\/p>\n<p style=\"background: white; vertical-align: baseline; margin: 0cm 0cm 7.5pt 0cm;\">Kupodivu jsou nositel\u00e9 t\u00e9to mutace zdrav\u00ed, bez jin\u00e9 poruchy imunity. T\u00e9\u017ee mutace lze vyu\u017e\u00edt v modern\u00ed bun\u011b\u010dn\u00e9 terapii k l\u00e9\u010db\u011b HIV naka\u017een\u00fdch pacient\u016f, nap\u0159. pomoc\u00ed transplantace hematopoetick\u00fdch kmenov\u00fdch bun\u011bk s mutac\u00ed CCR5 \u039432.<\/p>\n<p style=\"background: white; vertical-align: baseline; margin: 0cm 0cm 7.5pt 0cm;\">Tento typ bun\u011b\u010dn\u00e9 terapie bohu\u017eel s sebou p\u0159in\u00e1\u0161\u00ed mnoh\u00e1 \u00faskal\u00ed, proto je v sou\u010dasn\u00e9 dob\u011b st\u00e1le ve f\u00e1zi v\u00fdzkumu.<\/p>\n<p>&nbsp;<\/p>\n<p>Dal\u0161\u00ed podrobnosti naleznete na webov\u00fdch str\u00e1nk\u00e1ch <a href=\"http:\/\/www.qgen.cz\">www.qgen.cz<\/a><\/p>\n<p>Term\u00edn l\u00e9ka\u0159sk\u00e9ho vy\u0161et\u0159en\u00ed si m\u016f\u017eete rezervovat <a href=\"http:\/\/extranet.mc-praha.cz\/\">zde.<\/a><\/p>\n<p>Laboratorn\u00ed vy\u0161et\u0159en\u00ed si m\u016f\u017eete objednat<a href=\"https:\/\/extranet.mc-praha.cz\/#\/laboratory\"> zde<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; CCR5 je bun\u011b\u010dn\u00fd chemokinov\u00fd receptor a je podobn\u011b jako jin\u00e9 receptory vstupn\u00ed branou pro [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"link","meta":{"_uag_custom_page_level_css":""},"categories":[9],"tags":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"boldthemes_grid":false,"boldthemes_grid_11":false,"boldthemes_grid_22":false,"boldthemes_grid_21":false,"boldthemes_grid_12":false,"boldthemes_latest_posts":false,"boldthemes_grid_gallery":false},"uagb_author_info":{"display_name":"Jbednar","author_link":"https:\/\/www.mc-praha.cz\/mcp\/author\/jbednar\/"},"uagb_comment_info":0,"uagb_excerpt":"&nbsp; CCR5 je bun\u011b\u010dn\u00fd chemokinov\u00fd receptor a je podobn\u011b jako jin\u00e9 receptory vstupn\u00ed branou pro [&hellip;]","post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/2026"}],"collection":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/comments?post=2026"}],"version-history":[{"count":7,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/2026\/revisions"}],"predecessor-version":[{"id":4548,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/2026\/revisions\/4548"}],"wp:attachment":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/media?parent=2026"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/categories?post=2026"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/tags?post=2026"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}