<\/p>\n
V\u00fdzkum zam\u011b\u0159uj\u00edc\u00ed se na v\u00fdvoj vakc\u00edny proti rakovin\u011b je jedn\u00edm z\u00a0nejintenzivn\u011bj\u0161\u00edch. V\u011bdc\u016fm ze Stanfordsk\u00e9 univerzity se v\u00a0t\u00e9to oblasti povedlo ud\u011blat v\u00fdznamn\u00fd pokrok.<\/strong><\/p>\n Nejprve si v\u0161imli, \u017ee takzvan\u00e9 indukovan\u00e9 pluripotentn\u00ed kmenov\u00e9 bu\u0148ky (iPSCs) maj\u00ed na sv\u00e9m povrchu podobn\u00e9 znaky jako bu\u0148ky n\u00e1dorov\u00e9, a tak je napadlo vyu\u017e\u00edt iPSCs jako vakc\u00ednu.<\/p>\n iPSCs jsou um\u011ble vytvo\u0159en\u00e9 kmenov\u00e9 bu\u0148ky. Z\u00a0b\u011b\u017en\u00e9 bu\u0148ky (nap\u0159. z\u00a0k\u016f\u017ee nebo krve) se genetick\u00fdm z\u00e1sahem v\u00a0laborato\u0159i vytvo\u0159\u00ed pluripotentn\u00ed kmenov\u00e1 bu\u0148ka, kter\u00e1 nese podobn\u00e9 povrchov\u00e9 znaky jako bu\u0148ka n\u00e1dorov\u00e1. Za pomoci oz\u00e1\u0159en\u00ed se bu\u0148ka inaktivuje, tedy zbav\u00ed schopnosti d\u011blen\u00ed. Takto vytvo\u0159en\u00e1 vakc\u00edna \u201eu\u010d\u00ed\u201c imunitn\u00ed syst\u00e9m rozpozn\u00e1vat znaky n\u00e1dorov\u00fdch bun\u011bk a likvidovat je, pokud se n\u011bkdy v\u00a0t\u011ble vyskytnou.<\/p>\n Ve Stanfordu odebrali tk\u00e1\u0148ov\u00e9 bu\u0148ky n\u011bkolika lini\u00edm my\u0161\u00ed, vytvo\u0159ili z\u00a0nich iPSCs, inaktivovali je oz\u00e1\u0159en\u00edm a n\u00e1sledn\u011b je jednou t\u00fddn\u011b injikovali my\u0161\u00edm zp\u011bt. Po m\u011bs\u00edci terapie do my\u0161\u00ed vpravili n\u00e1dorov\u00e9 bu\u0148ky (konkr\u00e9tn\u011b pracovali s\u00a0bu\u0148kami rakoviny k\u016f\u017ee, rakoviny prsu a rakoviny plic) a srovn\u00e1vali v\u00fdvoj n\u00e1dor\u016f s\u00a0my\u0161mi, kter\u00fdm vakc\u00edna pod\u00e1na nebyla. U v\u0161ech my\u0161\u00ed vznikly n\u00e1dory, ale u 70 % vakcinovan\u00fdch \u010dasem do\u0161lo k\u00a0jejich v\u00fdrazn\u00e9mu zmen\u0161en\u00ed \u010di \u00fapln\u00e9mu vymizen\u00ed.<\/p>\n Pokud by se stejn\u00fd mechanismus v\u00fdvoje vakc\u00edny proti rakovin\u011b osv\u011bd\u010dil i u lid\u00ed, jednalo by se bezpochyby o pr\u016flomov\u00fd objev. Vakc\u00edna z\u00a0iPSCs m\u00e1 toti\u017e hned n\u011bkolik v\u00fdhod: je vytvo\u0159en\u00e1 z\u00a0pacientovi vlastn\u00edch bun\u011bk a t\u00edm p\u00e1dem nehroz\u00ed \u017e\u00e1dn\u00e9 v\u00fdrazn\u00e9 vedlej\u0161\u00ed \u00fa\u010dinky a nav\u00edc se zd\u00e1, \u017ee by jedna vakc\u00edna mohla b\u00fdt \u00fa\u010dinn\u00e1 proti n\u011bkolika druh\u016fm rakoviny z\u00e1rove\u0148.<\/p>\n Zdroj: KOOREMAN, Nigel G., et al. Autologous iPSC-based vaccines elicit anti-tumor responses in vivo.\u00a0Cell stem cell<\/em>, 2018, 22.4: 501-513. e7.<\/p>\n <\/p>\n","protected":false},"excerpt":{"rendered":" V\u00fdzkum zam\u011b\u0159uj\u00edc\u00ed se na v\u00fdvoj vakc\u00edny proti rakovin\u011b je jedn\u00edm z\u00a0nejintenzivn\u011bj\u0161\u00edch. V\u011bdc\u016fm ze Stanfordsk\u00e9 […]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":{"_uag_custom_page_level_css":""},"categories":[1],"tags":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"boldthemes_grid":false,"boldthemes_grid_11":false,"boldthemes_grid_22":false,"boldthemes_grid_21":false,"boldthemes_grid_12":false,"boldthemes_latest_posts":false,"boldthemes_grid_gallery":false},"uagb_author_info":{"display_name":"Jbednar","author_link":"https:\/\/www.mc-praha.cz\/mcp\/author\/jbednar\/"},"uagb_comment_info":0,"uagb_excerpt":" V\u00fdzkum zam\u011b\u0159uj\u00edc\u00ed se na v\u00fdvoj vakc\u00edny proti rakovin\u011b je jedn\u00edm z\u00a0nejintenzivn\u011bj\u0161\u00edch. V\u011bdc\u016fm ze Stanfordsk\u00e9 […]","post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/2897"}],"collection":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/comments?post=2897"}],"version-history":[{"count":4,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/2897\/revisions"}],"predecessor-version":[{"id":2911,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/2897\/revisions\/2911"}],"wp:attachment":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/media?parent=2897"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/categories?post=2897"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/tags?post=2897"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}