{"id":2922,"date":"2019-01-04T12:48:07","date_gmt":"2019-01-04T11:48:07","guid":{"rendered":"http:\/\/www.mc-praha.cz\/mcp\/?p=2922"},"modified":"2019-01-04T12:49:40","modified_gmt":"2019-01-04T11:49:40","slug":"za-neurodegenerativni-onemocneni-jsou-zrejme-zodpovedne-spatne-fungujici-mitochondrie","status":"publish","type":"post","link":"https:\/\/www.mc-praha.cz\/mcp\/za-neurodegenerativni-onemocneni-jsou-zrejme-zodpovedne-spatne-fungujici-mitochondrie\/","title":{"rendered":"Mitochondrie jsou z\u0159ejm\u011b zodpov\u011bdn\u00e9 za neurodegenerativn\u00ed onemocn\u011bn\u00ed"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p><strong>Za neurodegenerativn\u00ed onemocn\u011bn\u00ed jsou z\u0159ejm\u011b zodpov\u011bdn\u00e9 \u0161patn\u011b funguj\u00edc\u00ed mitochondrie. Nervov\u00e1 bu\u0148ka neboli neuron je charakteristick\u00e1 velk\u00fdm po\u010dtem v\u00fdb\u011b\u017ek\u016f (neurit\u016f), kter\u00fdmi je spojen\u00e1 s\u00a0ostatn\u00edmi neurony.<\/strong> Tyto neurity umo\u017e\u0148uj\u00ed komunikaci mezi bu\u0148kami a jsou zodpov\u011bdn\u00e9 za pam\u011b\u0165 a jin\u00e9 nervov\u00e9 funkce. Je zn\u00e1mo, \u017ee s\u00a0rostouc\u00edm v\u011bkem se neurity p\u0159irozen\u011b zkracuj\u00ed, ale nervov\u00e1 bu\u0148ka z\u016fst\u00e1v\u00e1 st\u00e1le funk\u010dn\u00ed. Oproti tomu u n\u011bkter\u00fdch neurodegenerativn\u00edch onemocn\u011bn\u00ed doch\u00e1z\u00ed ke zkracov\u00e1n\u00ed neurit\u016f ji\u017e v\u00a0mlad\u00e9m v\u011bku a je n\u00e1sledov\u00e1no odum\u0159en\u00edm nervov\u00e9 bu\u0148ky. Dosud nebyla pln\u011b objasn\u011bna p\u0159\u00ed\u010dina zkracov\u00e1n\u00ed neurit\u016f a i l\u00e9\u010dba neurodegenerativn\u00edch onemocn\u011bn\u00ed je zat\u00edm velmi omezen\u00e1.<\/p>\n<p>T\u00fdm v\u011bdc\u016f z\u00a0Pittsburghu se na neurit\u00f3zu, jak nazval zkracov\u00e1n\u00ed neurit\u016f, zam\u011b\u0159il a zd\u00e1 se, \u017ee objevil mo\u017enou p\u0159\u00ed\u010dinu. Ve studii zkoumali my\u0161i trp\u00edc\u00ed obdobou lidsk\u00e9 Huntingtonovy choroby a zjistili, \u017ee za zkracov\u00e1n\u00edm neurit\u016f pravd\u011bpodobn\u011b stoj\u00ed \u0161patn\u011b funguj\u00edc\u00ed mitochondrie (bun\u011b\u010dn\u00e9 organely z\u00e1sobuj\u00edc\u00ed bu\u0148ku energi\u00ed \u2013 jak\u00e9si \u201eelektr\u00e1rny\u201c). V\u00a0ka\u017ed\u00e9 bu\u0148ce se nach\u00e1z\u00ed n\u011bkolik set a\u017e n\u011bkolik tis\u00edc mitochondri\u00ed rozm\u00edst\u011bn\u00fdch po cel\u00e9m jej\u00edm objemu. My\u0161i trp\u00edc\u00ed Huntingtonovou chorobou maj\u00ed v\u00a0neuritech p\u0159\u00edtomn\u00e9 mitochondrie s\u00a0po\u0161kozenou membr\u00e1nou. Takov\u00e1 mitochondrie pak v\u00fdb\u011b\u017eek nedostate\u010dn\u011b z\u00e1sobuje energi\u00ed a spou\u0161t\u00ed proces, jeho\u017e v\u00fdsledkem je uvoln\u011bn\u00ed enzymu, kter\u00fd n\u00e1sledn\u011b zp\u016fsob\u00ed odum\u0159en\u00ed neuritu.<\/p>\n<p>L\u00e9k zabra\u0148uj\u00edc\u00ed po\u0161kozen\u00ed mitochondri\u00ed by tedy mohl b\u00fdt \u00fa\u010dinnou l\u00e9\u010dbou pro neurodegenerativn\u00ed onemocn\u011bn\u00ed.<\/p>\n<p>Zdroj: <a href=\"https:\/\/www.pnas.org\/content\/early\/2018\/12\/19\/1811021116.short?rss=1\">https:\/\/www.pnas.org\/content\/early\/2018\/12\/19\/1811021116.short?rss=1<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; Za neurodegenerativn\u00ed onemocn\u011bn\u00ed jsou z\u0159ejm\u011b zodpov\u011bdn\u00e9 \u0161patn\u011b funguj\u00edc\u00ed mitochondrie. Nervov\u00e1 bu\u0148ka neboli neuron je [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":{"_uag_custom_page_level_css":""},"categories":[1],"tags":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"boldthemes_grid":false,"boldthemes_grid_11":false,"boldthemes_grid_22":false,"boldthemes_grid_21":false,"boldthemes_grid_12":false,"boldthemes_latest_posts":false,"boldthemes_grid_gallery":false},"uagb_author_info":{"display_name":"Jbednar","author_link":"https:\/\/www.mc-praha.cz\/mcp\/author\/jbednar\/"},"uagb_comment_info":0,"uagb_excerpt":"&nbsp; Za neurodegenerativn\u00ed onemocn\u011bn\u00ed jsou z\u0159ejm\u011b zodpov\u011bdn\u00e9 \u0161patn\u011b funguj\u00edc\u00ed mitochondrie. Nervov\u00e1 bu\u0148ka neboli neuron je [&hellip;]","post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/2922"}],"collection":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/comments?post=2922"}],"version-history":[{"count":3,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/2922\/revisions"}],"predecessor-version":[{"id":2926,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/2922\/revisions\/2926"}],"wp:attachment":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/media?parent=2922"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/categories?post=2922"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/tags?post=2922"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}