<\/p>\n
Slo\u017een\u00ed mate\u0159sk\u00e9ho ml\u00e9ka se pod\u00edl\u00ed na utv\u00e1\u0159en\u00ed st\u0159evn\u00edho mikrobiomu kojence. Oligosacharidy obsa\u017een\u00e9 v\u00a0mate\u0159sk\u00e9m ml\u00e9ce (HMO, z\u00a0angl. human milk oligosaccharides), mikrobiom mate\u0159sk\u00e9ho ml\u00e9ka a st\u0159evn\u00ed\u00a0mikrobiota d\u00edt\u011bte ovliv\u0148uj\u00ed klinick\u00e9 projevy rotavirov\u00e9 infekce u kojenc\u016f.<\/strong><\/p>\n HMO, po lakt\u00f3ze a tuku, jsou t\u0159et\u00ed nejpo\u010detn\u011bj\u0161\u00ed pevnou slo\u017ekou mate\u0159sk\u00e9ho ml\u00e9ka. Slo\u017een\u00ed mate\u0159sk\u00e9ho ml\u00e9ka je u ka\u017ed\u00e9 koj\u00edc\u00ed matky individu\u00e1ln\u00ed a je ovlivn\u011bno zejm\u00e9na geneticky. Tud\u00ed\u017e i koncentrace HMO v\u00a0mate\u0159sk\u00e9m ml\u00e9ce je u ka\u017ed\u00e9 matky jin\u00e1. HMO jsou pro kojence nestraviteln\u00e9. V jeho st\u0159ev\u011b funguj\u00ed jako prebiotika a z\u00e1rove\u0148 HMO \u201emimikuj\u00ed\u201c cukern\u00e9 receptory na bu\u0148k\u00e1ch st\u0159evn\u00ed sliznice, na kter\u00e9 se patogenn\u00ed mikroorganismy v\u00e1\u017eou. HMO t\u00edmto chr\u00e1n\u00ed st\u0159evn\u00ed syst\u00e9m d\u00edt\u011bte a vytv\u00e1\u0159ej\u00ed vhodn\u00e9 prost\u0159ed\u00ed pro r\u016fst komenz\u00e1ln\u00edch bakteri\u00ed. P\u0159evaha komenz\u00e1ln\u00edch st\u0159evn\u00edch bakteri\u00ed br\u00e1n\u00ed uchycen\u00ed bakteri\u00ed patogenn\u00edch a t\u00edm je zaji\u0161t\u011bno spr\u00e1vn\u00e9 slo\u017een\u00ed st\u0159evn\u00ed mikrobioty.<\/p>\n Rotaviry jsou enterogenn\u00ed patogeny zp\u016fsobuj\u00edc\u00ed v\u00e1\u017en\u00e9 gastrointestin\u00e1ln\u00ed probl\u00e9my zejm\u00e9na u p\u0159ed\u0161koln\u00edch d\u011bt\u00ed. U novorozenc\u016f b\u00fdvaj\u00ed tyto infekce asymptomatick\u00e9, av\u0161ak v\u00a0n\u011bkter\u00fdch p\u0159\u00edpadech m\u00edvaj\u00ed rotavirov\u00e9 infekce z\u00e1va\u017en\u00fd pr\u016fb\u011bh i u novorozenc\u016f. Touto p\u0159\u00ed\u010dinou se zab\u00fdvali v\u011bdci z\u00a0Baylor College of Medicine v\u00a0Houstonu (USA). Zjistili, \u017ee HMO interaguj\u00ed ve st\u0159ev\u011b novorozence p\u0159\u00edmo s\u00a0viry jako takov\u00fdmi a specifick\u00e9 druhy HMO maj\u00ed vliv na infektivitu rotaviru. Nav\u00edc matky kojenc\u016f, kte\u0159\u00ed trp\u011bli gastrointestin\u00e1ln\u00edmi projevy rotavirov\u00e9 infekce, m\u011bly v\u00a0mate\u0159sk\u00e9m ml\u00e9ce vy\u0161\u0161\u00ed relativn\u00ed v\u00fdskyt bakteri\u00ed kmene Enterobacter\/Klebsiella<\/em> a ni\u017e\u0161\u00ed v\u00fdskyt bateri\u00ed kmene Streptococcus <\/em>a Staphylococcus <\/em>ne\u017e matky, jejich\u017e d\u011bti symptomy rotavirov\u00e9 infekce netrp\u011bly. Specifick\u00e9 slo\u017een\u00ed HMO a mikrobiomu mate\u0159sk\u00e9ho ml\u00e9ka tak m\u00e1 vliv na projevy rotavirov\u00e9 infekce u kojenc\u016f.<\/p>\n Zji\u0161t\u011bn\u00ed, \u017ee HMO mate\u0159sk\u00e9ho ml\u00e9ka maj\u00ed vliv na infektivitu jednotliv\u00fdch kmen\u016f rotavir\u016f, m\u00e1 potenci\u00e1l p\u0159i budouc\u00edm v\u00fdvoji nov\u00e9 lep\u0161\u00ed vakc\u00edny proti rotavir\u016fm.<\/p>\n Zdroj:<\/strong> Ramani, Sasirekha, et al. „Human milk oligosaccharides, milk microbiome and infant gut microbiome modulate neonatal rotavirus infection.“ Nature communications<\/em> 9.1 (2018): 5010.<\/p>\n <\/p>\n <\/p>\n <\/p>\n","protected":false},"excerpt":{"rendered":" Slo\u017een\u00ed mate\u0159sk\u00e9ho ml\u00e9ka se pod\u00edl\u00ed na utv\u00e1\u0159en\u00ed st\u0159evn\u00edho mikrobiomu kojence. Oligosacharidy obsa\u017een\u00e9 v\u00a0mate\u0159sk\u00e9m ml\u00e9ce […]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":{"_uag_custom_page_level_css":""},"categories":[1],"tags":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"boldthemes_grid":false,"boldthemes_grid_11":false,"boldthemes_grid_22":false,"boldthemes_grid_21":false,"boldthemes_grid_12":false,"boldthemes_latest_posts":false,"boldthemes_grid_gallery":false},"uagb_author_info":{"display_name":"Jbednar","author_link":"https:\/\/www.mc-praha.cz\/mcp\/author\/jbednar\/"},"uagb_comment_info":0,"uagb_excerpt":" Slo\u017een\u00ed mate\u0159sk\u00e9ho ml\u00e9ka se pod\u00edl\u00ed na utv\u00e1\u0159en\u00ed st\u0159evn\u00edho mikrobiomu kojence. Oligosacharidy obsa\u017een\u00e9 v\u00a0mate\u0159sk\u00e9m ml\u00e9ce […]","post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/2943"}],"collection":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/comments?post=2943"}],"version-history":[{"count":1,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/2943\/revisions"}],"predecessor-version":[{"id":2945,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/2943\/revisions\/2945"}],"wp:attachment":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/media?parent=2943"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/categories?post=2943"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/tags?post=2943"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}