<\/p>\n
Po\u010det neplodn\u00fdch p\u00e1r\u016f st\u00e1le roste, a proto je kl\u00ed\u010dov\u00e9 co nejl\u00e9pe porozum\u011bt cel\u00e9mu procesu oplodn\u011bn\u00ed, aby bylo mo\u017en\u00e9 analyzovat p\u0159esnou p\u0159\u00ed\u010dinu neplodnosti a n\u00e1sledn\u011b se ji pokusit odstranit.<\/p>\n
St\u00e1v\u00e1 se, \u017ee v\u00fdsledky spermiogramu mu\u017ee jsou v\u00a0po\u0159\u00e1dku, spermie maj\u00ed zdravou morfologii, je jich dostatek a jsou dostate\u010dn\u011b pohybliv\u00e9 a p\u0159esto se p\u00e1ru neda\u0159\u00ed po\u010d\u00edt.<\/p>\n
V\u011bdci z\u00a0univerzity Yale nyn\u00ed odhalili dal\u0161\u00ed mechanismus kl\u00ed\u010dov\u00fd pro schopnost spermi\u00ed oplodnit vaj\u00ed\u010dko. Jedn\u00e1 se o iontov\u00fd kan\u00e1l CatSper, kter\u00fd se nach\u00e1z\u00ed v\u00a0membr\u00e1n\u011b bi\u010d\u00edku spermie. Jak spermie putuje \u017eensk\u00fdm pohlavn\u00edm \u00fastroj\u00edm, m\u011bn\u00ed se i okoln\u00ed podm\u00ednky. V\u00a0okam\u017eiku, kdy se p\u0159ibl\u00ed\u017e\u00ed k vaj\u00ed\u010dku, odli\u0161n\u00e9 pH (zm\u011bna kyselosti) okoln\u00edho prost\u0159ed\u00ed otev\u0159e kan\u00e1l CatSper, \u010d\u00edm\u017e zp\u016fsob\u00ed, \u017ee spermie za\u010dne usilovn\u011bji mrskat bi\u010d\u00edkem a p\u0159estane \u0161et\u0159it energi\u00ed. K\u00a0tomu, aby m\u00ed\u0159ila spr\u00e1vn\u00fdm sm\u011brem, j\u00ed napom\u00e1haj\u00ed tak\u00e9 receptory detekuj\u00edc\u00ed koncentraci hormonu progesteronu (v okol\u00ed vaj\u00ed\u010dka se hodnota zvy\u0161uje). Jsou-li tedy kan\u00e1ly CatSper nefunk\u010dn\u00ed, nebo funguj\u00ed jen omezen\u011b, v\u00fdrazn\u011b to sni\u017euje mo\u017enost po\u010det\u00ed, p\u0159esto\u017ee jinak se spermie zdaj\u00ed b\u00fdt v\u00a0po\u0159\u00e1dku.<\/p>\n
Tento poznatek je kl\u00ed\u010dov\u00fd pro budouc\u00ed diagnostiku neplodnosti a n\u00e1slednou l\u00e9\u010dbu. Ji\u017e te\u010f ale v\u011bdci navrhuj\u00ed, \u017ee na CatSper kan\u00e1lech by mohl b\u00fdt zalo\u017een princip nov\u00e9 antikoncepce, kter\u00e1 by se obe\u0161la bez hormon\u016f.<\/p>\n
Zdroj: HWANG, Jae Yeon, et al. Dual Sensing of Physiologic pH and Calcium by EFCAB9 Regulates Sperm Motility.\u00a0Cell<\/em>, 2019.<\/p>\n <\/p>\n","protected":false},"excerpt":{"rendered":" Po\u010det neplodn\u00fdch p\u00e1r\u016f st\u00e1le roste, a proto je kl\u00ed\u010dov\u00e9 co nejl\u00e9pe porozum\u011bt cel\u00e9mu procesu […]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":{"_uag_custom_page_level_css":""},"categories":[1],"tags":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"boldthemes_grid":false,"boldthemes_grid_11":false,"boldthemes_grid_22":false,"boldthemes_grid_21":false,"boldthemes_grid_12":false,"boldthemes_latest_posts":false,"boldthemes_grid_gallery":false},"uagb_author_info":{"display_name":"Jbednar","author_link":"https:\/\/www.mc-praha.cz\/mcp\/author\/jbednar\/"},"uagb_comment_info":0,"uagb_excerpt":" Po\u010det neplodn\u00fdch p\u00e1r\u016f st\u00e1le roste, a proto je kl\u00ed\u010dov\u00e9 co nejl\u00e9pe porozum\u011bt cel\u00e9mu procesu […]","post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/3114"}],"collection":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/comments?post=3114"}],"version-history":[{"count":1,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/3114\/revisions"}],"predecessor-version":[{"id":3116,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/3114\/revisions\/3116"}],"wp:attachment":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/media?parent=3114"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/categories?post=3114"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/tags?post=3114"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}