<\/p>\n
T\u00fdm v\u011bdc\u016f z USA ve sv\u00e9 studii zkoumal spojitost mezi slo\u017een\u00edm mikrobiomu k\u016f\u017ee (zam\u011b\u0159ili se p\u0159edev\u0161\u00edm na bakterii Staphylococcus aureus<\/em>) a atopickou dermatitidou neboli ekz\u00e9mem.<\/p>\n Ekz\u00e9m se prezentuje jako skvrny hrub\u00e9 k\u016f\u017ee, kter\u00e9 v\u00a0akutn\u00edch f\u00e1z\u00edch tvo\u0159\u00ed puch\u00fd\u0159e vedouc\u00ed k nutkav\u00e9mu sv\u011bd\u011bn\u00ed, \u0161kr\u00e1b\u00e1n\u00ed a n\u00e1sledn\u011b i krv\u00e1cen\u00ed. Prudk\u00e1 zarudlost se projev\u00ed zvl\u00e1\u0161t\u011b kdy\u017e imunitn\u00ed syst\u00e9m reaguje p\u0159ehnan\u011b na stimul a zah\u00e1j\u00ed \u00fatok na ko\u017en\u00ed bari\u00e9ru. P\u0159es zna\u010dn\u00e9 mno\u017estv\u00ed v\u00fdzkum\u016f zat\u00edm nen\u00ed p\u0159esn\u011b zn\u00e1m\u00e1 jeho p\u0159\u00ed\u010dina a ani efektivn\u00ed l\u00e9\u010dba.<\/p>\n Ji\u017e n\u011bkter\u00e9 p\u0159edchoz\u00ed studie nazna\u010dily, \u017ee by mohlo existovat spojen\u00ed mezi atopickou dermatitidou a ko\u017en\u00edm mikrobiomem. V\u00a0t\u00e9to pr\u00e1ci se v\u011bdci zam\u011b\u0159ili na konkr\u00e9tn\u00ed bakterii, Stapyhlococcus aureus<\/em>, a jej\u00ed souvislost s ekz\u00e9my.<\/p>\n P\u0159edchoz\u00ed v\u00fdzkum uk\u00e1zal, \u017ee S. aureus<\/em> je hojn\u011bj\u0161\u00ed na k\u016f\u017ei lid\u00ed, kte\u0159\u00ed trp\u00ed ekz\u00e9my. Bakterie tak\u00e9 produkuje peptidy zp\u016fsobuj\u00edc\u00ed oslaben\u00ed bun\u011bk tvo\u0159\u00edc\u00edch ko\u017en\u00ed bari\u00e9ru, co\u017e m\u00e1 za n\u00e1sledek pronik\u00e1n\u00ed stafylokoka do ni\u017e\u0161\u00edch vrstev k\u016f\u017ee a vznik akutn\u00edch f\u00e1z\u00ed dermatitidy.<\/p>\n Krom\u011b t\u011bchto nep\u0159\u00edli\u0161 p\u0159\u00edzniv\u00fdch objev\u016f ale tak\u00e9 odhalili, \u017ee v\u00a0mikrobiomu lidsk\u00e9 k\u016f\u017ee se vyskytuj\u00ed i bakterie schopn\u00e9 omezovat p\u016fsoben\u00ed S. aureus<\/em>. Tyto bakterie neutralizuj\u00ed peptidy produkovan\u00e9 stafylokokem, \u010d\u00edm\u017e dok\u00e1\u017e\u00ed zamezit vzniku akutn\u00ed f\u00e1ze onemocn\u011bn\u00ed. Ve studii tak byli v\u011bdci schopn\u00ed zm\u00edrnit akutn\u00ed f\u00e1zi ekz\u00e9mu u my\u0161\u00ed, jim\u017e na k\u016f\u017ei p\u0159enesli mikrobiom zdrav\u00fdch my\u0161\u00ed.<\/p>\n V\u00fdsledky studie by mohly b\u00fdt p\u0159\u00ednosn\u00e9 zvl\u00e1\u0161t\u011b pro v\u00fdvoj budouc\u00ed l\u00e9\u010dby atopick\u00e9 dermatitidy.<\/p>\n <\/p>\n Zdroj: Michael R. Williams et al. Quorum sensing between bacterial species on the skin protects against epidermal injury in atopic dermatitis, Science Translational Medicine<\/em> (2019). DOI: 10.1126\/scitranslmed.aat8329<\/p>\n","protected":false},"excerpt":{"rendered":" T\u00fdm v\u011bdc\u016f z USA ve sv\u00e9 studii zkoumal spojitost mezi slo\u017een\u00edm mikrobiomu k\u016f\u017ee (zam\u011b\u0159ili […]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":{"_uag_custom_page_level_css":""},"categories":[1],"tags":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"boldthemes_grid":false,"boldthemes_grid_11":false,"boldthemes_grid_22":false,"boldthemes_grid_21":false,"boldthemes_grid_12":false,"boldthemes_latest_posts":false,"boldthemes_grid_gallery":false},"uagb_author_info":{"display_name":"Jbednar","author_link":"https:\/\/www.mc-praha.cz\/mcp\/author\/jbednar\/"},"uagb_comment_info":0,"uagb_excerpt":" T\u00fdm v\u011bdc\u016f z USA ve sv\u00e9 studii zkoumal spojitost mezi slo\u017een\u00edm mikrobiomu k\u016f\u017ee (zam\u011b\u0159ili […]","post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/3122"}],"collection":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/comments?post=3122"}],"version-history":[{"count":1,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/3122\/revisions"}],"predecessor-version":[{"id":3124,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/3122\/revisions\/3124"}],"wp:attachment":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/media?parent=3122"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/categories?post=3122"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/tags?post=3122"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}