<\/p>\n
V\u00a0souvislosti s ned\u00e1vno zve\u0159ejn\u011bnou informac\u00ed, kdy \u010d\u00ednsk\u00fd v\u011bdec editoval genom dvoj\u010dat pomoc\u00ed modern\u00ed technologie CRISPR a vnesl tak do genomu embry\u00ed mutaci podobnou p\u0159irozen\u011b se vyskytuj\u00edc\u00ed mutaci genu CCR5<\/em>, byla publikov\u00e1na studie zab\u00fdvaj\u00edc\u00ed se dal\u0161\u00edmi funk\u010dn\u00edmi projevy mutovan\u00e9 formy tohoto genu. <\/em>Mutace je ozna\u010dovan\u00e1 jako \u039432 a chr\u00e1n\u00ed homozygotn\u00ed jedince (tj. ty, kte\u0159\u00ed zd\u011bdili tuto stejnou formu genu CCR5<\/em> od otce i od matky) p\u0159ed n\u00e1kazou virem HIV. Dal\u0161\u00ed jednozna\u010dn\u00e9 vn\u011bj\u0161\u00ed projevy genu CCR5- \u039432 <\/em>v\u0161ak prozat\u00edm nebyly prozkoum\u00e1ny. V\u011bdci z\u00a0USA pomoc\u00ed genotypizace a statistick\u00e9ho zpracov\u00e1n\u00ed dat z\u00a0registru \u00famrt\u00ed ve Velk\u00e9 Brit\u00e1nii (UK Biobank) zjistili, \u017ee jedinci s genem CCR5-\u039432<\/em> maj\u00ed o 20% men\u0161\u00ed \u0161anci do\u017eit\u00ed 76 let ne\u017e jedinci s\u00a0odli\u0161n\u00fdm genotypem. Nav\u00edc ji\u017e d\u0159\u00edve bylo pozorov\u00e1no, \u017ee homozygotn\u00ed jedinci s\u00a0mutac\u00ed \u039432 maj\u00ed zv\u00fd\u0161enou \u00famrtnost p\u0159i n\u00e1kaze virem ch\u0159ipky a maj\u00ed \u010dty\u0159ikr\u00e1t v\u011bt\u0161\u00ed riziko k\u00a0rozvoji infek\u010dn\u00edch onemocn\u011bn\u00ed. Z\u0159ejm\u011b tedy je pozitivn\u00ed efekt mutace \u039432 v\u00a0genu CCR5<\/em> v\u00a0podob\u011b ochrany p\u0159ed n\u00e1kazou virem HIV vyva\u017eov\u00e1n negativn\u00edmi d\u016fsledky, a to vy\u0161\u0161\u00ed \u00famrtnost\u00ed a vy\u0161\u0161\u00ed predispozic\u00ed k\u00a0n\u00e1kaze b\u011b\u017en\u00fdmi infek\u010dn\u00edmi onemocn\u011bn\u00edmi.<\/p>\n Zdroj<\/strong>: Wei, Xinzhu, and Rasmus Nielsen. „CCR5-\u2206 32 is deleterious in the homozygous state in humans.“ Nature Medicine<\/em> (2019): 1.<\/p>\n","protected":false},"excerpt":{"rendered":" V\u00a0souvislosti s ned\u00e1vno zve\u0159ejn\u011bnou informac\u00ed, kdy \u010d\u00ednsk\u00fd v\u011bdec editoval genom dvoj\u010dat pomoc\u00ed modern\u00ed technologie […]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":{"_uag_custom_page_level_css":""},"categories":[1],"tags":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"boldthemes_grid":false,"boldthemes_grid_11":false,"boldthemes_grid_22":false,"boldthemes_grid_21":false,"boldthemes_grid_12":false,"boldthemes_latest_posts":false,"boldthemes_grid_gallery":false},"uagb_author_info":{"display_name":"Jbednar","author_link":"https:\/\/www.mc-praha.cz\/mcp\/author\/jbednar\/"},"uagb_comment_info":0,"uagb_excerpt":" V\u00a0souvislosti s ned\u00e1vno zve\u0159ejn\u011bnou informac\u00ed, kdy \u010d\u00ednsk\u00fd v\u011bdec editoval genom dvoj\u010dat pomoc\u00ed modern\u00ed technologie […]","post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/3135"}],"collection":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/comments?post=3135"}],"version-history":[{"count":1,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/3135\/revisions"}],"predecessor-version":[{"id":3137,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/3135\/revisions\/3137"}],"wp:attachment":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/media?parent=3135"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/categories?post=3135"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/tags?post=3135"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}