<\/p>\n
V\u00fdzkum L\u00e9ka\u0159sk\u00e9 fakulty Univerzity v Hong Kongu (HKUMed), institutu Wellcome Sanger a Institutu Friedrich-Loeffler v N\u011bmecku nab\u00edz\u00ed nov\u00fd potenci\u00e1l pro studium lidsk\u00e9ho rozvoje a regenerativn\u00ed medic\u00edny.<\/p>\n
Nov\u00fd p\u0159\u00edstup umo\u017enil v\u00fdzkumn\u00edk\u016fm vytvo\u0159it tzv. kmenov\u00e9 bu\u0148ky s\u00a0roz\u0161\u00ed\u0159en\u00fdm potenci\u00e1lem (Expanded Potential Stem Cells \u2013 EPSCs) z prase\u010d\u00edch i lidsk\u00fdch bun\u011bk. Tyto kmenov\u00e9 bu\u0148ky jsou tzv. totipotentn\u00ed. A\u017e doposud bylo mo\u017en\u00e9 pracovat pouze s\u00a0bu\u0148kami pluripotentn\u00edmi, kter\u00e9 vznikaj\u00ed z\u00a0bun\u011bk totipotentn\u00edch a mohou se p\u0159em\u011bnit v\u00a0jakoukoliv bu\u0148ku lidsk\u00e9ho t\u011bla krom\u011b bu\u0148ky totipotentn\u00ed. Vytvo\u0159en\u00ed EPSCs tedy posouv\u00e1 v\u011bdce k\u00a0v\u00fdzkumu v\u0161ech typ\u016f bun\u011bk nach\u00e1zej\u00edc\u00edch se v\u00a0lidsk\u00e9m t\u011ble, v\u010detn\u011b totipotentn\u00edch.<\/p>\n
Prvn\u00ed EPSCs byly vytvo\u0159eny v roce 2017, ale jednalo se o EPSCs my\u0161\u00edho p\u016fvodu. Nyn\u00ed je ji\u017e z\u0159ejm\u00e9, \u017ee je mo\u017en\u00e9 pou\u017e\u00edt stejn\u00fd p\u0159\u00edstup k tvorb\u011b lidsk\u00fdch a prase\u010d\u00edch EPSCs. Konkr\u00e9tn\u011b jsou vytvo\u0159eny kultivac\u00ed bun\u011bk nejran\u011bj\u0161\u00edho st\u00e1dia v\u00fdvoje (po rozd\u011blen\u00ed oplodn\u011bn\u00e9ho vaj\u00ed\u010dka pouze na 4 nebo 8 bun\u011bk).<\/p>\n
EPSCs maj\u00ed schopnost produkovat v\u0161echny embryon\u00e1ln\u00ed a extra-embryon\u00e1ln\u00ed bun\u011b\u010dn\u00e9 linie, v\u010detn\u011b bun\u011bk v placent\u011b a \u017eloutkov\u00fdch v\u00e1\u010dc\u00edch, \u010d\u00edm\u017e se nab\u00edzej\u00ed nov\u00e9 mo\u017enosti pro zkoum\u00e1n\u00ed komplikac\u00ed t\u011bhotenstv\u00ed, jako jsou preeklampsie a potraty a tak\u00e9 mohou umo\u017enit studium \u010dasn\u00e9ho embryon\u00e1ln\u00edho v\u00fdvoje a v\u00fdvojov\u00fdch poruch. Velk\u00fd potenci\u00e1l EPSCs je tak\u00e9 v\u00a0oblasti regenerativn\u00ed medic\u00edny, transplantaci org\u00e1n\u016f \u010di modelov\u00e1n\u00ed nemoc\u00ed.<\/p>\n
Zdroj<\/strong>: GAO, Xuefei, et al. Establishment of porcine and human expanded potential stem cells.\u00a0Nature cell biology<\/i>, 2019, 21.6: 687.<\/p>\n","protected":false},"excerpt":{"rendered":" V\u00fdzkum L\u00e9ka\u0159sk\u00e9 fakulty Univerzity v Hong Kongu (HKUMed), institutu Wellcome Sanger a Institutu Friedrich-Loeffler […]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":{"_uag_custom_page_level_css":""},"categories":[1],"tags":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"boldthemes_grid":false,"boldthemes_grid_11":false,"boldthemes_grid_22":false,"boldthemes_grid_21":false,"boldthemes_grid_12":false,"boldthemes_latest_posts":false,"boldthemes_grid_gallery":false},"uagb_author_info":{"display_name":"Jbednar","author_link":"https:\/\/www.mc-praha.cz\/mcp\/author\/jbednar\/"},"uagb_comment_info":0,"uagb_excerpt":" V\u00fdzkum L\u00e9ka\u0159sk\u00e9 fakulty Univerzity v Hong Kongu (HKUMed), institutu Wellcome Sanger a Institutu Friedrich-Loeffler […]","post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/3143"}],"collection":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/comments?post=3143"}],"version-history":[{"count":1,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/3143\/revisions"}],"predecessor-version":[{"id":3145,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/3143\/revisions\/3145"}],"wp:attachment":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/media?parent=3143"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/categories?post=3143"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/tags?post=3143"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}