<\/p>\n
V bl\u00edzk\u00e9 budoucnosti by se mohlo za\u010d\u00edt pou\u017e\u00edvat nov\u00e9 l\u00e9\u010divo pro pacienty s\u00a0diabetem typu 2, zejm\u00e9na pak pro rezistentn\u00ed typy diabetu. Ned\u00e1vn\u00e1 studie proveden\u00e1 v Indii uk\u00e1zala, \u017ee hydroxychloroquine dosahuje v\u00a0l\u00e9\u010db\u011b rezistentn\u00edho diabetu typu 2 podobn\u00fdch \u00fa\u010dink\u016f jako standardn\u00ed l\u00e9k canagliflozin (Invokana, Janssen). Krom\u011b toho p\u0159isp\u00edv\u00e1 k\u00a0redukci hmotnosti (BMI) a tak\u00e9 sni\u017euje riziko srde\u010dn\u00edch onemocn\u011bn\u00ed, co\u017e dokazuj\u00ed sn\u00ed\u017een\u00e9 hladiny hsCRP (high sensitivity C – reactive protein) u pacient\u016f, kte\u0159\u00ed u\u017e\u00edvali hydroxychloroquine .<\/p>\n
Tato l\u00e1tka je ji\u017e dlouh\u00e1 l\u00e9ta pou\u017e\u00edv\u00e1na jako antimalarikum a nyn\u00ed se zd\u00e1, \u017ee by se jej\u00ed vyu\u017eit\u00ed mohlo roz\u0161\u00ed\u0159it tak\u00e9 na l\u00e9\u010dbu diabetu. P\u0159esto\u017ee na prvn\u00ed pohled nen\u00ed z\u0159ejm\u00e1 \u017e\u00e1dn\u00e1 souvislost mezi malarickou infekc\u00ed a diabetem druh\u00e9ho typu, nen\u00ed pou\u017eit\u00ed ji\u017e zaveden\u00e9ho l\u00e9ku pro jin\u00e1 onemocn\u011bn\u00ed nikterak neobvykl\u00e1 ud\u00e1lost. Nap\u0159\u00edklad aspirin se v n\u00edzk\u00fdch d\u00e1vk\u00e1ch pou\u017e\u00edv\u00e1 k l\u00e9\u010db\u011b bolesti, zat\u00edmco vy\u0161\u0161\u00ed d\u00e1vka slou\u017e\u00ed k prevenci vzniku krevn\u00ed sra\u017eeniny (prevence mrtvice).<\/p>\n
Nav\u00edc, my\u0161lenka \u017ee hydroxychloroquine m\u016f\u017ee p\u016fsobit u pacient\u016f s\u00a0cukrovkou je zn\u00e1ma ji\u017e od pades\u00e1t\u00fdch let minul\u00e9ho stolet\u00ed. V Indii byl schv\u00e1len ji\u017e v roce 2014 jako alternativa pro pacienty, kte\u0159\u00ed nereagovali na dva typy peror\u00e1ln\u00edch antidiabetik.<\/p>\n
Ne\u017e bude mo\u017en\u00e9 rutinn\u00ed pou\u017eit\u00ed hydroxychloroquinu v\u00a0l\u00e9\u010db\u011b diabetu tak\u00e9 v Evrop\u011b, je samoz\u0159ejm\u011b nutn\u00e9 prov\u00e9st klinick\u00e9 studie zahrnuj\u00edc\u00ed vy\u0161\u0161\u00ed po\u010det pacient\u016f, ale vzhledem k\u00a0tomu, \u017ee se jedn\u00e1 o ji\u017e zaveden\u00fd l\u00e9k, nem\u011blo by se jednat o p\u0159\u00edli\u0161 n\u00e1ro\u010dn\u00fd proces.<\/p>\n
<\/p>\n
Zdroj:<\/strong> Gupta A, et al. A real-world observational comparative study for the efficacy and tolerability of hydroxychloroquine vs. canagliflozin in Indian type 2 diabetes patients having inadequate glycemic control on vildagliptin plus metformin. Presented at: AACE Annual Scientific and Clinical Congress; April 24-28, 2019; Los Angeles.<\/p>\n","protected":false},"excerpt":{"rendered":" V bl\u00edzk\u00e9 budoucnosti by se mohlo za\u010d\u00edt pou\u017e\u00edvat nov\u00e9 l\u00e9\u010divo pro pacienty s\u00a0diabetem typu […]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":{"_uag_custom_page_level_css":""},"categories":[1],"tags":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"boldthemes_grid":false,"boldthemes_grid_11":false,"boldthemes_grid_22":false,"boldthemes_grid_21":false,"boldthemes_grid_12":false,"boldthemes_latest_posts":false,"boldthemes_grid_gallery":false},"uagb_author_info":{"display_name":"Jbednar","author_link":"https:\/\/www.mc-praha.cz\/mcp\/author\/jbednar\/"},"uagb_comment_info":0,"uagb_excerpt":" V bl\u00edzk\u00e9 budoucnosti by se mohlo za\u010d\u00edt pou\u017e\u00edvat nov\u00e9 l\u00e9\u010divo pro pacienty s\u00a0diabetem typu […]","post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/3147"}],"collection":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/comments?post=3147"}],"version-history":[{"count":1,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/3147\/revisions"}],"predecessor-version":[{"id":3149,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/3147\/revisions\/3149"}],"wp:attachment":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/media?parent=3147"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/categories?post=3147"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/tags?post=3147"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}