{"id":3704,"date":"2020-11-23T10:15:11","date_gmt":"2020-11-23T09:15:11","guid":{"rendered":"https:\/\/www.mc-praha.cz\/mcp\/?p=3704"},"modified":"2020-11-23T10:15:11","modified_gmt":"2020-11-23T09:15:11","slug":"vedci-objevili-protein-ktery-nas-chrani-pred-lymskou-boreliozou","status":"publish","type":"post","link":"https:\/\/www.mc-praha.cz\/mcp\/vedci-objevili-protein-ktery-nas-chrani-pred-lymskou-boreliozou\/","title":{"rendered":"V\u011bdci objevili protein, kter\u00fd n\u00e1s chr\u00e1n\u00ed p\u0159ed lymskou boreli\u00f3zou"},"content":{"rendered":"<p>Lymsk\u00e1 boreli\u00f3za je velice z\u00e1va\u017en\u00fdm infek\u010dn\u00edm onemocn\u011bn\u00edm p\u0159en\u00e1\u0161en\u00fdm hmyzem, nej\u010dast\u011bji zakousnut\u00edm kl\u00ed\u0161t\u011bte. Jedn\u00edm z\u00a0bakteri\u00e1ln\u00edch druh\u016f, kter\u00e9 tuto nemoc zp\u016fsobuj\u00ed, je spirocheta <em>Borrelia burgdorferi<\/em>. Naka\u017een\u00ed jedinci \u010dasto maj\u00ed nulov\u00e9 nebo jen slab\u00e9 p\u0159\u00edznaky. Pokud je nemoc podchycena v\u010das, d\u00e1 se \u00fasp\u011b\u0161n\u011b vyl\u00e9\u010dit antibiotiky. V\u00a0pozd\u011bj\u0161\u00edch st\u00e1di\u00edch napad\u00e1 srdce, nervov\u00fd syst\u00e9m a jin\u00e9 t\u011blesn\u00e9 org\u00e1ny. V\u00fdsledky v\u011bdeck\u00e9 studie z\u00a0Yale University \u201e<strong>A human secretome library screen reveals a role for Peptidoglycan Recognition Protein 1 in Lyme borreliosis\u201c<\/strong> odhaluj\u00ed protein, kter\u00fd je sv\u00e1z\u00e1n se signalizac\u00ed lymsk\u00fdch spirochet.<\/p>\n<p>Za \u00fa\u010delem odhalen\u00ed biologicky relevantn\u00edch interakc\u00ed bylo zkoum\u00e1no p\u0159es 1 000 lidsk\u00fdch gen\u016f proti 36 izol\u00e1t\u016fm boreli\u00ed. Bylo zji\u0161t\u011bno, \u017ee protein peptidoglycan recognition protein 1 (PGLYRP1) se p\u0159i styku s bakteri\u00ed chov\u00e1 jako varovn\u00fd signaliz\u00e1tor s\u00a0boreliacidn\u00edmi \u00fa\u010dinky. PGLYRP1 dok\u00e1\u017ee usmrcovat tyto bakterie prost\u0159ednictv\u00edm nav\u00e1z\u00e1n\u00ed na jejich vn\u011bj\u0161\u00ed membr\u00e1nu a aktivovat cytoplasmatickou regulaci l\u00e1tek. T\u00edm dojde k vytvo\u0159en\u00ed nedostatku oxid\u016f, thiol\u016f a kov\u016f v bakterii, a ta n\u00e1sledn\u011b um\u00edr\u00e1.<\/p>\n<p>U my\u0161\u00ed bez proteinu PGLYRP1 byla zji\u0161t\u011bna v\u011bt\u0161\u00ed n\u00e1lo\u017e <em>B. burgdorferi<\/em> ne\u017e u t\u011bch, kter\u00e9 jeho p\u0159\u00edtomnost vykazovaly. Stimulace tvorby tohoto proteinu by proto mohla hr\u00e1t v boji s\u00a0lymskou boreli\u00f3zou velice d\u016fle\u017eitou roli.<\/p>\n<p>Profesor Erol Fikrig a jeho kolegov\u00e9 z\u00a0Yale University n\u00e1sledn\u011b zkoumaj\u00ed, zda jsou lid\u00e9 s vy\u0161\u0161\u00edmi hodnotami PGLYRP1 m\u00e9n\u011b citliv\u00ed k infekci <em>B. burgdorferi<\/em>, co\u017e by vysv\u011btlovalo, pro\u010d n\u011bkte\u0159\u00ed naka\u017een\u00ed jedinci maj\u00ed leh\u010d\u00ed pr\u016fb\u011bh onemocn\u011bn\u00ed ne\u017e ostatn\u00ed.<\/p>\n<p>&nbsp;<\/p>\n<p>Zdroj:<\/p>\n<p>Gupta A, Arora G, Rosen CE, Kloos Z, Cao Y, Cerny J, Sajid A, Hoornstra D, Golovchenko M, Rudenko N, Munderloh U, Hovius JW, Booth CJ, Jacobs-Wagner CH, Palm NW, Ring AM, Fikrig E (2020): A human secretome library screen reveals a role for Peptidoglycan Recognition Protein 1 in Lyme borreliosis. PLOS Pathogens, 16, 1-21.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lymsk\u00e1 boreli\u00f3za je velice z\u00e1va\u017en\u00fdm infek\u010dn\u00edm onemocn\u011bn\u00edm p\u0159en\u00e1\u0161en\u00fdm hmyzem, nej\u010dast\u011bji zakousnut\u00edm kl\u00ed\u0161t\u011bte. Jedn\u00edm z\u00a0bakteri\u00e1ln\u00edch druh\u016f, [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"image","meta":{"_uag_custom_page_level_css":""},"categories":[1],"tags":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"boldthemes_grid":false,"boldthemes_grid_11":false,"boldthemes_grid_22":false,"boldthemes_grid_21":false,"boldthemes_grid_12":false,"boldthemes_latest_posts":false,"boldthemes_grid_gallery":false},"uagb_author_info":{"display_name":"Jbednar","author_link":"https:\/\/www.mc-praha.cz\/mcp\/author\/jbednar\/"},"uagb_comment_info":0,"uagb_excerpt":"Lymsk\u00e1 boreli\u00f3za je velice z\u00e1va\u017en\u00fdm infek\u010dn\u00edm onemocn\u011bn\u00edm p\u0159en\u00e1\u0161en\u00fdm hmyzem, nej\u010dast\u011bji zakousnut\u00edm kl\u00ed\u0161t\u011bte. Jedn\u00edm z\u00a0bakteri\u00e1ln\u00edch druh\u016f, [&hellip;]","post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/3704"}],"collection":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/comments?post=3704"}],"version-history":[{"count":1,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/3704\/revisions"}],"predecessor-version":[{"id":3705,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/3704\/revisions\/3705"}],"wp:attachment":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/media?parent=3704"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/categories?post=3704"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/tags?post=3704"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}