{"id":4184,"date":"2022-02-10T09:32:14","date_gmt":"2022-02-10T08:32:14","guid":{"rendered":"https:\/\/www.mc-praha.cz\/mcp\/?p=4184"},"modified":"2022-02-11T11:24:55","modified_gmt":"2022-02-11T10:24:55","slug":"vakcina-nuvaxovid-nova-nadeje-v-boji-proti-viru-sars-cov-2","status":"publish","type":"post","link":"https:\/\/www.mc-praha.cz\/mcp\/vakcina-nuvaxovid-nova-nadeje-v-boji-proti-viru-sars-cov-2\/","title":{"rendered":"Vakc\u00edna Nuvaxovid \u2013 nov\u00e1 nad\u011bje v boji proti viru SARS-CoV-2"},"content":{"rendered":"<p><em>Pandemie koronaviru je tu s n\u00e1mi t\u00e9m\u011b\u0159 dva roky, v pr\u016fb\u011bhu kter\u00fdch se podle statistik WHO potvrdilo v\u00edce ne\u017e 373 mili\u00f3n\u016f p\u0159\u00edpad\u016f COVID-19 a v\u00edce ne\u017e 5 mili\u00f3n\u016f lid\u00ed t\u00e9to z\u00e1ke\u0159n\u00e9 nemoci podlehlo. Navzdory v\u00fdvoji nov\u00fdch l\u00e9k\u016f proti viru SARS-CoV-2 z\u016fst\u00e1v\u00e1 prioritou \u010d. 1 o\u010dkov\u00e1n\u00ed. Od\u00a0<\/em><em>1. \u00fanora 2022 se v\u00a0\u010cR spou\u0161t\u00ed registrace na o\u010dkov\u00e1n\u00ed p\u00e1tou z \u0159ady vakc\u00edn proti viru SARS-CoV-2, tentokr\u00e1t od spole\u010dnosti Novavax. <\/em><\/p>\n<p>Vakc\u00edna s obchodn\u00edm n\u00e1zvem Nuvaxovid vyr\u00e1b\u011bn\u00e1 spole\u010dnost\u00ed Novavax pat\u0159\u00ed mezi proteinov\u00e9 vakc\u00edny na b\u00e1zi nano\u010d\u00e1stic. Tato technologie zahrnuje vlo\u017een\u00ed genu k\u00f3duj\u00edc\u00edho spike glykoprotein (S-protein) do bakuloviru (BV) a n\u00e1sledn\u011b jsou pomoc\u00ed BV infikov\u00e1ny hmyz\u00ed bu\u0148ky <em>Sf9<\/em> (odvozeny od m\u016fry <em>Spodoptera frugiperda<\/em>). V\u00a0t\u011bchto bu\u0148k\u00e1ch se vytvo\u0159\u00ed velik\u00e9 mno\u017estv\u00ed S-proteinu, kter\u00e9 se sbal\u00ed do formy nano\u010d\u00e1stice. T\u00edmto zp\u016fsobem jsou \u010d\u00e1stice S-proteinu p\u0159ipraven\u00e9 na pou\u017eit\u00ed. Pro pos\u00edlen\u00ed imunitn\u00ed reakce je do vakc\u00edny p\u0159id\u00e1n M-Matrix<sup>TM<\/sup> adjuvans na b\u00e1zi saponinu.<\/p>\n<p>Pokud je \u010dlov\u011bk nao\u010dkov\u00e1n touto vakc\u00ednou, imunitn\u00ed syst\u00e9m rozpozn\u00e1 S-protein jako cizorodou l\u00e1tku a za\u010dne produkovat neutraliza\u010dn\u00ed protil\u00e1tky, aktivuj\u00ed se CD4+ a CD8+ T-bu\u0148ky a stimuluj\u00ed se pam\u011b\u0165ov\u00e9 B-bu\u0148ky. P\u0159i st\u0159etnut\u00ed s virem SARS-CoV-2 je imunitn\u00ed syst\u00e9m schopen rychleji rozpoznat virov\u00fd S-protein a br\u00e1nit se v\u016f\u010di n\u011bmu.<\/p>\n<p>V\u00a0letech 2020\u20132021 prob\u011bhlo n\u011bkolik studi\u00ed zam\u011b\u0159en\u00fdch na \u00fa\u010dinnost a bezpe\u010dnost vakc\u00edny. V\u00a0prvn\u00ed polovin\u011b roku 2021 byla realizov\u00e1na t\u0159et\u00ed f\u00e1ze randomizovan\u00e9, placebem kontrolovan\u00e9 klinick\u00e9 studie, kter\u00e9 se z\u00fa\u010dastnilo t\u00e9m\u011b\u0159 30\u00a0000 osob nad 18 let poch\u00e1zej\u00edc\u00edch z\u00a0Mexika a USA, s r\u016fznou etnickou p\u0159\u00edslu\u0161nost\u00ed a r\u016fzn\u00fdm zdravotn\u00edm stavem (zdrav\u00ed dobrovoln\u00edci i pacienti se stabilizovan\u00fdm chronick\u00fdm onemocn\u011bn\u00edm, nap\u0159. chronick\u00e9 ren\u00e1ln\u00ed, kardiovaskul\u00e1rn\u00ed nebo plicn\u00ed onemocn\u011bn\u00ed, diabetes mellitus 2. typu, pacienti s\u00a0HIV aj.). P\u0159ibli\u017en\u011b dv\u011b t\u0159etiny \u00fa\u010dastn\u00edk\u016f byly o\u010dkov\u00e1ny vakc\u00ednou Nuvaxovid, ostatn\u00edm \u00fa\u010dastn\u00edk\u016fm bylo pod\u00e1no placebo (tj. d\u00e1vka bez \u00fa\u010dinn\u00e9 l\u00e1tky). V\u00a0pr\u016fb\u011bhu t\u00e9to studie p\u0159evl\u00e1daly v\u00a0Mexiku a USA varianty viru SARS-CoV-2 alfa (B.1.1.7), beta (B.1.351), gama (P.1), epsilon (B.1.427 a B. 1.429) a iota (B.1.526).<\/p>\n<p>V\u00fdsledky studie uk\u00e1zaly, \u017ee \u00fa\u010dinnost vakc\u00edny Nuvaxovid proti variant\u00e1m SARS-CoV-2, kter\u00e9 v\u00a0dob\u011b studie dominovaly, celkov\u011b dosahovala p\u0159ibli\u017en\u011b 90 %. Od pacient\u016f o\u010dkovan\u00fdch touto vakc\u00ednou, kte\u0159\u00ed onemocn\u011bli COVID-19, byly hl\u00e1\u0161eny m\u00edrn\u00e9 pot\u00ed\u017ee, zat\u00edmco u pacient\u016f s\u00a0placebem se objevovaly st\u0159edn\u011b t\u011b\u017ek\u00e9 a\u017e t\u011b\u017ek\u00e9 p\u0159\u00edznaky onemocn\u011bn\u00ed. Nej\u010dast\u011bji hl\u00e1\u0161en\u00fdmi vedlej\u0161\u00edmi \u00fa\u010dinky vakcinace byly bolest v\u00a0m\u00edst\u011b vpichu, bolest hlavy, svalstva (myalgie), \u00fanava a mal\u00e1tnost, kter\u00e9 trvaly necel\u00fd jeden den. Z\u00e1va\u017en\u00e9 syst\u00e9mov\u00e9 reakce se objevily p\u0159ev\u00e1\u017en\u011b u o\u010dkovan\u00fdch pacient\u016f po druh\u00e9 d\u00e1vce, av\u0161ak jejich v\u00fdskyt byl m\u00e9n\u011b \u010dast\u00fd ne\u017e u doposud pou\u017e\u00edvan\u00fdch koronavirov\u00fdch vakc\u00edn.<\/p>\n<p>Na z\u00e1klad\u011b v\u00fdsledk\u016f dosavadn\u00edch studi\u00ed je mo\u017en\u00e9 pova\u017eovat vakc\u00ednu Nuvaxovid od spole\u010dnosti Novavax za bezpe\u010dnou, poskytuj\u00edc\u00ed vysokou ochranu proti p\u016fvodn\u00edmu viru SARS-Cov-2 a alfa a beta variant\u00e1m. Prozat\u00edm z\u016fst\u00e1vaj\u00ed omezeny \u00fadaje k \u00fa\u010dinnosti v\u016f\u010di variant\u011b omikron (B. 1.1.529).<\/p>\n<p>Mgr. Krist\u00edna \u0160urekov\u00e1<\/p>\n<p>9.2.2022<\/p>\n<p><strong>Zdroje:<\/strong><\/p>\n<p><a href=\"https:\/\/www.sukl.cz\/nuvaxovid-otazky-a-odpovedi-k-vakcine-od-spolecnosti-novavax\">https:\/\/www.sukl.cz\/nuvaxovid-otazky-a-odpovedi-k-vakcine-od-spolecnosti-novavax<\/a><br \/>\n<a href=\"https:\/\/covid19.who.int\/\">https:\/\/covid19.who.int\/<\/a><\/p>\n<p>Tian JH, Patel N, Zhou H et al. (2021): SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice. Nature Communications, 12, 1-14. doi: 10.1038\/s41467-020-20653-8.<\/p>\n<p>Dunkle LM, Kotloff KL, Gay CL et al. (2021): Efficacy and safety of NVX-CoV2373 in adults in the United States and Mexico. The New England Journal of Medicine, NEJMoa2116185. doi: 10.1056\/NEJMoa2116185.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pandemie koronaviru je tu s n\u00e1mi t\u00e9m\u011b\u0159 dva roky, v pr\u016fb\u011bhu kter\u00fdch se podle statistik [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"image","meta":{"_uag_custom_page_level_css":""},"categories":[1],"tags":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"boldthemes_grid":false,"boldthemes_grid_11":false,"boldthemes_grid_22":false,"boldthemes_grid_21":false,"boldthemes_grid_12":false,"boldthemes_latest_posts":false,"boldthemes_grid_gallery":false},"uagb_author_info":{"display_name":"Jbednar","author_link":"https:\/\/www.mc-praha.cz\/mcp\/author\/jbednar\/"},"uagb_comment_info":0,"uagb_excerpt":"Pandemie koronaviru je tu s n\u00e1mi t\u00e9m\u011b\u0159 dva roky, v pr\u016fb\u011bhu kter\u00fdch se podle statistik [&hellip;]","post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/4184"}],"collection":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/comments?post=4184"}],"version-history":[{"count":4,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/4184\/revisions"}],"predecessor-version":[{"id":4187,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/4184\/revisions\/4187"}],"wp:attachment":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/media?parent=4184"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/categories?post=4184"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/tags?post=4184"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}