{"id":4268,"date":"2022-09-23T18:26:25","date_gmt":"2022-09-23T16:26:25","guid":{"rendered":"https:\/\/www.mc-praha.cz\/mcp\/?p=4268"},"modified":"2022-09-23T18:26:25","modified_gmt":"2022-09-23T16:26:25","slug":"vymena-krve-jako-potencialni-lecba-poskozeni-mozku-v-dusledku-alzheimerovy-choroby","status":"publish","type":"post","link":"https:\/\/www.mc-praha.cz\/mcp\/vymena-krve-jako-potencialni-lecba-poskozeni-mozku-v-dusledku-alzheimerovy-choroby\/","title":{"rendered":"V\u00fdm\u011bna krve jako potenci\u00e1ln\u00ed l\u00e9\u010dba po\u0161kozen\u00ed mozku v d\u016fsledku Alzheimerovy choroby"},"content":{"rendered":"<p><em>Alzheimerova choroba (AD) je chronick\u00e9 progresivn\u00ed onemocn\u011bn\u00ed mozku, kter\u00e9 se vyzna\u010duje poruchami u\u010den\u00ed a pam\u011bti. Je nej\u010dast\u011bj\u0161\u00ed p\u0159\u00ed\u010dinou demence u star\u0161\u00ed populace. Navzdory mnohalet\u00e9mu \u00fasil\u00ed porozum\u011bt genetick\u00fdm a molekul\u00e1rn\u00edm z\u00e1klad\u016fm AD nen\u00ed dosud k dispozici \u00fa\u010dinn\u00e1 terapie tohoto z\u00e1va\u017en\u00e9ho onemocn\u011bn\u00ed. Av\u0161ak zd\u00e1 se, \u017ee lidstvo by nyn\u00ed mohlo b\u00fdt o krok bl\u00ed\u017ee k\u00a0jeho poko\u0159en\u00ed.<\/em><\/p>\n<p>P\u0159esv\u011bd\u010div\u00e9 d\u016fkazy nazna\u010duj\u00ed, \u017ee v\u00a0onemocn\u011bn\u00ed AD hraje \u00fast\u0159edn\u00ed roli chybn\u00e9 skl\u00e1d\u00e1n\u00ed, agregace a cerebr\u00e1ln\u00ed ukl\u00e1d\u00e1n\u00ed amyloidu-beta (A\u03b2). Odstran\u011bn\u00ed chybn\u011b poskl\u00e1dan\u00fdch proteinov\u00fdch agreg\u00e1t\u016f A\u03b2 z krve by podle v\u011bdc\u016f mohlo pomoci zpomalit progresi t\u00e9to nemoci.<\/p>\n<p>V l\u00e9ka\u0159sk\u00e9 praxi se ji\u017e vyu\u017e\u00edvaj\u00ed metody na \u010di\u0161t\u011bn\u00ed krve jako je plazmafer\u00e9za nebo krevn\u00ed dial\u00fdza, kter\u00e9 mohou sn\u00ed\u017eit hromad\u011bn\u00ed toxick\u00fdch l\u00e1tek i v\u00a0mozku, a to bez nutnosti p\u0159\u00edm\u00fdch invazivn\u00edch z\u00e1krok\u016f.<\/p>\n<p>T\u00fdm v\u011bdc\u016f z\u00a0institutu UTHealth Houston opakovan\u011b testoval v\u00fdm\u011bnu pln\u00e9 krve na my\u0161\u00edch posti\u017een\u00fdch cerebr\u00e1ln\u00edm ukl\u00e1d\u00e1n\u00edm amyloidn\u00edch prekurzorov\u00fdch protein\u016f, kter\u00e9 jsou spojen\u00e9 s v\u00fdskytem AD. T\u011bmto my\u0161\u00edm byla transferov\u00e1na krev od zdrav\u00fdch jedinc\u016f se stejn\u00fdm genetick\u00fdm pozad\u00edm. V\u00fdsledky jsou velice slibn\u00e9, nebo\u0165 v\u00fdvoj cerebr\u00e1ln\u00edch amyloidn\u00edch plak\u016f se v modelu AD na transgenn\u00edch my\u0161\u00edch sn\u00ed\u017eil o 40\u201380 %. T\u00e9\u017e se zlep\u0161ila prostorov\u00e1 pam\u011b\u0165 u star\u00fdch my\u0161\u00ed s amyloidn\u00ed patologi\u00ed a sn\u00ed\u017eila se rychlost tvorby plaku.<\/p>\n<p>P\u0159esn\u00fd mechanismus, kter\u00fdm v\u00fdm\u011bna krve sni\u017euje amyloidn\u00ed patologii a zlep\u0161uje pam\u011b\u0165, nen\u00ed v sou\u010dasn\u00e9 dob\u011b zn\u00e1m. Ale\u00a0efekt l\u00e9\u010dby zac\u00edlen\u00e9 na odstran\u011bn\u00ed agreg\u00e1t\u016f A\u03b2 z\u00a0krevn\u00edho ob\u011bhu potvrzen\u00e9 zat\u00edm pouze na my\u0161\u00edm modelu ukazuje, \u017ee se m\u016f\u017ee jednat o jednu z nejslibn\u011bj\u0161\u00edch l\u00e9\u010debn\u00fdch strategi\u00ed AD.<\/p>\n<p>V\u00a0Medic\u00ednsk\u00e9m centru Praha mohou pacienti absolvovat nejr\u016fzn\u011bj\u0161\u00ed genetick\u00e9 anal\u00fdzy a vy\u0161et\u0159en\u00ed v\u010detn\u011b vy\u0161et\u0159en\u00ed na p\u0159\u00edtomnost alel HLA-B7 a APOE. Tyto alely jsou spojen\u00e9 se zv\u00fd\u0161en\u00fdm rizikem AD. Je zde mo\u017enost absolvovat konzultaci s\u00a0l\u00e9ka\u0159em, \u010di pouze samotn\u00e9ho laboratorn\u00edho vy\u0161et\u0159en\u00ed.\u00a0V\u00edce informac\u00ed naleznete na webov\u00fdch str\u00e1nk\u00e1ch\u00a0<a href=\"https:\/\/www.qgen.cz\/\">https:\/\/www.qgen.cz\/<\/a>.<\/p>\n<p>Ing. V\u00edt Smejkal<\/p>\n<ol start=\"23\">\n<li>09. 2022<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<p>Zdroje: Urayama A, Moreno-Gonzales I, Morales-Scheihing D, Kharat V, Pritzkow S, Soto C. (2022): Preventive and therapeutic reduction of amyloid deposition and behavioral impairments in a model of Alzheimer\u2019s disease by whole blood exchange. Molecular Psychiatry. doi: <a href=\"http:\/\/dx.doi.org\/10.1038\/s41380-022-01679-4\">10.1038\/s41380-022-01679-4<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Alzheimerova choroba (AD) je chronick\u00e9 progresivn\u00ed onemocn\u011bn\u00ed mozku, kter\u00e9 se vyzna\u010duje poruchami u\u010den\u00ed a pam\u011bti. [&hellip;]<\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"image","meta":{"_uag_custom_page_level_css":""},"categories":[1],"tags":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"boldthemes_grid":false,"boldthemes_grid_11":false,"boldthemes_grid_22":false,"boldthemes_grid_21":false,"boldthemes_grid_12":false,"boldthemes_latest_posts":false,"boldthemes_grid_gallery":false},"uagb_author_info":{"display_name":"Ane\u017eka Klubalov\u00e1","author_link":"https:\/\/www.mc-praha.cz\/mcp\/author\/aklubalova\/"},"uagb_comment_info":0,"uagb_excerpt":"Alzheimerova choroba (AD) je chronick\u00e9 progresivn\u00ed onemocn\u011bn\u00ed mozku, kter\u00e9 se vyzna\u010duje poruchami u\u010den\u00ed a pam\u011bti. 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