{"id":4294,"date":"2023-02-06T12:20:23","date_gmt":"2023-02-06T11:20:23","guid":{"rendered":"https:\/\/www.mc-praha.cz\/mcp\/?p=4294"},"modified":"2023-02-06T12:20:23","modified_gmt":"2023-02-06T11:20:23","slug":"syngenni-transplantace-kmenovych-bunek-u-adolescenta-s-tumorem-mozku","status":"publish","type":"post","link":"https:\/\/www.mc-praha.cz\/mcp\/syngenni-transplantace-kmenovych-bunek-u-adolescenta-s-tumorem-mozku\/","title":{"rendered":"Syng\u00e9nn\u00ed transplantace kmenov\u00fdch bun\u011bk u adolescenta s tumorem mozku"},"content":{"rendered":"<p><strong>V\u00fdjime\u010dn\u00e1 p\u0159\u00edpadov\u00e1 studie informovala o transplantaci hematopoetick\u00fdch kmenov\u00fdch bun\u011bk od p\u0159\u00edbuzn\u00e9ho, kterou provedl t\u00fdm l\u00e9ka\u0159sk\u00fdch specialist\u016f ze \u0160pan\u011blska. Pacientem je 14let\u00fd chlapec s\u00a0diagn\u00f3zou bifok\u00e1ln\u00edho mozkov\u00e9ho tumoru.<\/strong><\/p>\n<p>Pacient byl nejprve l\u00e9\u010den podle standardn\u00edho protokolu. Podstoupil intenzivn\u00ed chemoterapii zac\u00edlenou na tumor mozku, pravd\u011bpodobn\u011b ze z\u00e1rode\u010dn\u00fdch bun\u011bk, a posl\u00e9ze chirurgickou resekci s\u00a0v\u00fdsledkem rezidu\u00e1ln\u00edho tumoru.<\/p>\n<p>V\u00a0dal\u0161\u00ed f\u00e1zi l\u00e9\u010dby l\u00e9ka\u0159i zvolili mo\u017enost syng\u00e9nn\u00ed transplantace hematopoetick\u00fdch kmenov\u00fdch bun\u011bk od jednovaje\u010dn\u00e9ho dvoj\u010dete pacienta. Stejn\u00e1 genetick\u00e1 v\u00fdbava byla prok\u00e1zan\u00e1 komplexn\u00ed anal\u00fdzou. P\u0159ed transplantac\u00ed byla indikov\u00e1na mobilizace perifern\u00edch kmenov\u00fdch bun\u011bk sourozenc\u016f. Odb\u011br kmenov\u00fdch bun\u011bk (afer\u00e9za) d\u00e1rce prob\u011bhl bez z\u00e1va\u017en\u011bj\u0161\u00edch komplikac\u00ed dle p\u0159\u00edslu\u0161n\u00e9ho protokolu pro kontinu\u00e1ln\u00ed sb\u011br monoklon\u00e1ln\u00edch bun\u011bk.<\/p>\n<p>Mobilizace perifern\u00edch kmenov\u00fdch bun\u011bk pacienta byla ne\u00fasp\u011b\u0161n\u00e1. Pacientovi byl v\u00a0kombinaci s\u00a0intenzivn\u00ed chemoterapi\u00ed transplantov\u00e1n syngenn\u00ed \u0161t\u011bp, kter\u00fd obsahoval hematopoetick\u00e9 kmenov\u00e9 bu\u0148ky. Hlavn\u00ed posttransplanta\u010dn\u00ed komplikac\u00ed byla sepse vyvolan\u00e1 bakteri\u00ed <em>Escherichia coli<\/em>, t\u011b\u017ek\u00e9 zvracen\u00ed a z\u00e1n\u011bt sliznic. Po transplantaci pacient dost\u00e1val preventivn\u011b antivirotika a antibiotika po dobu 4 m\u011bs\u00edc\u016f a pokra\u010doval v\u00a0pl\u00e1novan\u00e9 lok\u00e1ln\u00ed radia\u010dn\u00ed terapii. L\u00e9\u010dbu ukon\u010dil 8 m\u011bs\u00edc\u016f od stanoven\u00ed diagn\u00f3zy, toho \u010dasu je v\u00a0kompletn\u00ed remisi.<\/p>\n<p>Syng\u00e9nn\u00ed transplantace hematopoetick\u00fdch kmenov\u00fdch bun\u011bk u dosp\u011bl\u00fdch vykazuj\u00ed pom\u011brn\u011b rychl\u00e9 zhojen\u00ed a velmi n\u00edzkou incidenci reakce \u0161t\u011bpu proti hostiteli. U d\u011bt\u00ed s\u00a0tumorem mozku je tato transplantace velmi raritn\u00ed. L\u00e9ka\u0159i pacient\u016fv zdravotn\u00ed stav nad\u00e1le bedliv\u011b sleduj\u00ed.<\/p>\n<p>L\u00e9\u010debn\u00fd potenci\u00e1l kmenov\u00fdch bun\u011bk je p\u0159edm\u011btem mnoha v\u011bdeck\u00fdch studi\u00ed, jejich\u017e z\u00e1v\u011bry ukazuj\u00ed, \u017ee kmenov\u00e9 bu\u0148ky jsou perspektivn\u00edm terapeutick\u00fdm prost\u0159edkem v oblasti preventivn\u00ed a regenerativn\u00ed medic\u00edny i l\u00e9\u010dby nejr\u016fzn\u011bj\u0161\u00edch onemocn\u011bn\u00ed.<\/p>\n<p>MUDr. Adriana Kulkov\u00e1<\/p>\n<p>03.02.2023<\/p>\n<p>Zdroj:<\/p>\n<p>S\u00e1nchez-Sierra et al. (2023): Syngeneic hematopoietic stem cell transplantation after mobilization failure in an adolescent with intracranial germ cell tumor. Pediatric Blood and Cancer, e30177.\u00a0<a href=\"https:\/\/doi.org\/10.1002\/pbc.30177\">https:\/\/doi.org\/10.1002\/pbc.30177<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>V\u00fdjime\u010dn\u00e1 p\u0159\u00edpadov\u00e1 studie informovala o transplantaci hematopoetick\u00fdch kmenov\u00fdch bun\u011bk od p\u0159\u00edbuzn\u00e9ho, kterou provedl t\u00fdm l\u00e9ka\u0159sk\u00fdch [&hellip;]<\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"image","meta":{"_uag_custom_page_level_css":""},"categories":[1],"tags":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"boldthemes_grid":false,"boldthemes_grid_11":false,"boldthemes_grid_22":false,"boldthemes_grid_21":false,"boldthemes_grid_12":false,"boldthemes_latest_posts":false,"boldthemes_grid_gallery":false},"uagb_author_info":{"display_name":"Ane\u017eka Klubalov\u00e1","author_link":"https:\/\/www.mc-praha.cz\/mcp\/author\/aklubalova\/"},"uagb_comment_info":0,"uagb_excerpt":"V\u00fdjime\u010dn\u00e1 p\u0159\u00edpadov\u00e1 studie informovala o transplantaci hematopoetick\u00fdch kmenov\u00fdch bun\u011bk od p\u0159\u00edbuzn\u00e9ho, kterou provedl t\u00fdm l\u00e9ka\u0159sk\u00fdch [&hellip;]","post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/4294"}],"collection":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/comments?post=4294"}],"version-history":[{"count":1,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/4294\/revisions"}],"predecessor-version":[{"id":4297,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/4294\/revisions\/4297"}],"wp:attachment":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/media?parent=4294"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/categories?post=4294"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/tags?post=4294"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}