{"id":4354,"date":"2023-07-14T12:25:52","date_gmt":"2023-07-14T10:25:52","guid":{"rendered":"https:\/\/www.mc-praha.cz\/mcp\/?p=4354"},"modified":"2023-07-14T12:25:52","modified_gmt":"2023-07-14T10:25:52","slug":"vyuziti-kmenovych-bunek-v-lecbe-cukrovky-1-typu","status":"publish","type":"post","link":"https:\/\/www.mc-praha.cz\/mcp\/vyuziti-kmenovych-bunek-v-lecbe-cukrovky-1-typu\/","title":{"rendered":"Vyu\u017eit\u00ed kmenov\u00fdch bun\u011bk v l\u00e9\u010db\u011b cukrovky 1. typu"},"content":{"rendered":"<p><strong>Cukrovka 1. typu (C1T) je choroba zp\u016fsoben\u00e1 autoimunitn\u00edm z\u00e1n\u011btem, kdy t\u011blo \u00fato\u010d\u00ed na Langerhansovy ostr\u016fvky slinivky b\u0159i\u0161n\u00ed\u00a0produkuj\u00edc\u00ed inzulin. Ten slou\u017e\u00ed pro \u017eivotn\u011b d\u016fle\u017eit\u00fd transport gluk\u00f3zy z\u00a0krve do bun\u011bk. Jakmile jsou ostr\u016fvky slinivky b\u0159i\u0161n\u00ed imunitn\u00edm syst\u00e9mem zni\u010deny, pacient se st\u00e1v\u00e1 zcela z\u00e1visl\u00fdm na pod\u00e1v\u00e1n\u00ed inzulinu. O kmenov\u00fdch bu\u0148k\u00e1ch je zn\u00e1mo, \u017ee maj\u00ed \u0161irok\u00fd terapeutick\u00fd potenci\u00e1l. U C1T, zp\u016fsoben\u00e9 ztr\u00e1tou ur\u010dit\u00e9ho typu bun\u011bk, se bun\u011b\u010dn\u00e1 terapie jev\u00ed jako velmi vhodn\u00e1 l\u00e9\u010debn\u00e1 strategie. V\u00a0tomto p\u0159\u00edpad\u011b v\u0161ak zat\u00edm \u010dek\u00e1 na sv\u00e9 \u0161ir\u0161\u00ed vyu\u017eit\u00ed.<\/strong><\/p>\n<p>Jednou z\u00a0mo\u017enost\u00ed l\u00e9\u010dby C1T je transplantace slinivky b\u0159i\u0161n\u00ed od vhodn\u00e9ho d\u00e1rce, kter\u00e1 vede k\u00a0obnov\u011b tvorby inzulinu. Jde v\u0161ak o finan\u010dn\u011b n\u00e1ro\u010dnou z\u00e1le\u017eitost prov\u00e1d\u011bnou na vysoce specializovan\u00fdch pracovi\u0161t\u00edch, kter\u00e1 pro pacienta obn\u00e1\u0161\u00ed dosti vysokou m\u00edru z\u00e1t\u011b\u017ee a rizika. Oproti tomu by l\u00e9\u010dba C1T kmenov\u00fdmi bu\u0148kami mohla b\u00fdt m\u00e9n\u011b komplikovan\u00e1 a \u0161\u00ed\u0159eji dostupn\u00e1, mimo jin\u00e9 z\u00a0d\u016fvodu ni\u017e\u0161\u00ed finan\u010dn\u00ed n\u00e1ro\u010dnosti a vyu\u017eitelnosti laboratorn\u011b mno\u017een\u00fdch bun\u011bk.<\/p>\n<p>V\u00a0posledn\u00edch letech prob\u011bhla \u0159ada klinick\u00fdch studi\u00ed, kter\u00e9 testovaly potenci\u00e1ln\u00ed vyu\u017eit\u00ed lidsk\u00fdch pluripotentn\u00edch kmenov\u00fdch bun\u011bk v\u00a0l\u00e9\u010db\u011b C1T. Tyto bu\u0148ky jsou schopn\u00e9 diferencovat se na r\u016fzn\u00e9 bun\u011b\u010dn\u00e9 typy dle prost\u0159ed\u00ed, do kter\u00e9ho jsou implantov\u00e1ny. Nejprve se testovala kapslov\u00e1 implantace pluripotentn\u00edch kmenov\u00fdch bun\u011bk do slinivky b\u0159i\u0161n\u00ed. Kapsle v\u0161ak br\u00e1nila vylu\u010dov\u00e1n\u00ed inzulinu z\u00a0implant\u00e1tu. Ve\u00a0druh\u00e9 studii, kter\u00e1 st\u00e1le prob\u00edh\u00e1, v\u011bdci implantovali do slinivky kmenov\u00e9 bu\u0148ky na propustn\u011bj\u0161\u00edm nosi\u010di. Dle p\u0159edb\u011b\u017en\u00fdch v\u00fdsledk\u016f jsou bu\u0148ky schopny vylu\u010dovat inzulin a jin\u00e9 l\u00e9\u010div\u00e9 p\u016fsobky do okol\u00ed a c\u00e9vy ze slinivky b\u0159i\u0161n\u00ed pronikaj\u00ed do implant\u00e1tu. Pror\u016fst\u00e1n\u00ed c\u00e9vn\u00ed vaskulaturou je nutn\u00e9 pro p\u0159e\u017eit\u00ed kmenov\u00fdch bun\u011bk. Zat\u00edm nebyla zv\u00fd\u0161en\u00e1 produkce inzulinu v\u00a0krevn\u00edm ob\u011bhu zaznamen\u00e1na, v\u00fdsledky v\u0161ak nejsou fin\u00e1ln\u00ed.<\/p>\n<p>Jedn\u00edm z\u00a0probl\u00e9m\u016f, na kter\u00e9 v\u00fdzkumn\u00edci p\u0159i pou\u017eit\u00ed pluripotentn\u00edch bun\u011bk v\u00a0l\u00e9\u010db\u011b C1T nar\u00e1\u017eej\u00ed, jsou individu\u00e1ln\u00ed rozd\u00edly v\u00a0diferenciaci bun\u011bk. N\u011bkter\u00fdm pacient\u016fm se tvo\u0159\u00ed v\u00edce bun\u011bk produkuj\u00edc\u00edch inzulin a jin\u00fdm m\u00e9n\u011b. Proto se jev\u00ed vhodn\u011bj\u0161\u00ed aplikovat pacient\u016fm rovnou diferencovan\u00e9, inzulin produkuj\u00edc\u00ed beta bu\u0148ky. To potvrzuje studie zapo\u010dat\u00e1 v roce 2021. Jej\u00ed p\u0159edb\u011b\u017en\u00e9 v\u00fdsledky jsou slibn\u00e9 a ukazuj\u00ed, \u017ee tato forma bun\u011b\u010dn\u00e9 terapie zlep\u0161ila stav pacient\u016f s\u00a0C1T.<\/p>\n<p>Mgr. Lenka Gmiterkov\u00e1<\/p>\n<p>12.7.2023<\/p>\n<p>Zdroj:<\/p>\n<p>Hogrebe NJ, Ishahak M, Millman JR (2023): Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes. Cell Stem Cell, 5, 530-548.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cukrovka 1. typu (C1T) je choroba zp\u016fsoben\u00e1 autoimunitn\u00edm z\u00e1n\u011btem, kdy t\u011blo \u00fato\u010d\u00ed na Langerhansovy ostr\u016fvky [&hellip;]<\/p>\n","protected":false},"author":12,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"image","meta":{"_uag_custom_page_level_css":""},"categories":[1],"tags":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"boldthemes_grid":false,"boldthemes_grid_11":false,"boldthemes_grid_22":false,"boldthemes_grid_21":false,"boldthemes_grid_12":false,"boldthemes_latest_posts":false,"boldthemes_grid_gallery":false},"uagb_author_info":{"display_name":"Ane\u017eka Klubalov\u00e1","author_link":"https:\/\/www.mc-praha.cz\/mcp\/author\/aklubalova\/"},"uagb_comment_info":0,"uagb_excerpt":"Cukrovka 1. typu (C1T) je choroba zp\u016fsoben\u00e1 autoimunitn\u00edm z\u00e1n\u011btem, kdy t\u011blo \u00fato\u010d\u00ed na Langerhansovy ostr\u016fvky [&hellip;]","post_mailing_queue_ids":[],"_links":{"self":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/4354"}],"collection":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/comments?post=4354"}],"version-history":[{"count":1,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/4354\/revisions"}],"predecessor-version":[{"id":4356,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/posts\/4354\/revisions\/4356"}],"wp:attachment":[{"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/media?parent=4354"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/categories?post=4354"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.mc-praha.cz\/mcp\/wp-json\/wp\/v2\/tags?post=4354"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}